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– No Refrigeration required- simply activate with cold water Keeps Insulin Cool and Safe Reusable, Lightweight and Compact Maintains a safe temperature of 18-26°C, even in a constant environmental temperatures of 37.8°C Keeps cool for 45hrs minimum, and with a quick re-soak the wallet can be activated for a further 45hrs minimum In-use Insulin is safe in a FRIO wallet for up to 28 days (as per the life of in-use insulin kept above fridge-temperature)